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Option B best meets all stated requirements by correctly combining PII protection, evaluation before launch, and data residency compliance using Amazon Bedrock Guardrails. Amazon Bedrock guardrails provide native sensitive information filtering that operates inline during model invocation, making them well suited for preventing personal data exposure in customer-facing AI assistants.

The requirement to evaluate how effective the AI assistant is at preventing exposure before release is best addressed by using mask mode during development and testing. Mask mode allows responses to be generated while automatically redacting detected personal information, making it easy for developers and reviewers to see where and how PII would have appeared. This provides concrete validation that the guardrail rules are correctly configured without fully blocking responses, which is ideal for quality assurance and pre-production evaluation.

For production, switching the guardrail to block mode ensures that responses containing personal information are fully prevented from being returned to users. This offers the strongest protection and aligns with compliance expectations for customer account data. Block mode is appropriate once confidence in the guardrail configuration has been established during testing.

The data residency requirement is addressed by deploying a copy of the guardrail in each AWS Region where the application operates. Amazon Bedrock guardrails are Region-specific resources, and using Region-local guardrails ensures that inference, filtering, and enforcement all occur within the same Region as the customer data. This avoids cross-Region processing and helps the company comply with regulatory and contractual data residency policies.

Option A and D incorrectly rely on cross-Region guardrails, which can violate data residency constraints. Option C focuses on topic filtering rather than sensitive information filtering and keeps detect mode enabled in production, which does not actively prevent PII exposure. Therefore, B is the only option that fully satisfies safety, compliance, and evaluation requirements.

Option B provides the least operational overhead because it keeps the solution primarily inside managed Amazon Bedrock capabilities, minimizing custom orchestration code and infrastructure to operate. The core requirements are domain grounding, reduced semantic dilution for complex questions, and consistent low-latency responses at high request volume. A Bedrock knowledge base is purpose-built for Retrieval Augmented Generation by ingesting domain documents, chunking content, generating embeddings, and retrieving the most relevant passages at runtime. This directly addresses the need to reference domain-specific medical terminology from authoritative documents to reduce ambiguity and improve factual accuracy.

Reducing semantic dilution typically requires improving the retrieval query so that the retriever focuses on the most relevant concepts, especially for long or multi-intent questions. Enabling query decomposition allows the system to break a complex medical query into smaller, more targeted sub-queries. This increases retrieval precision and recall for each sub-question, which helps the model generate a more accurate synthesized response grounded in the retrieved medical context.

Amazon Bedrock Flows provide a managed way to orchestrate multi-step generative AI workflows, such as preprocessing the input, performing retrieval against the knowledge base, invoking a foundation model, and formatting the final response. Because flows are managed, the company avoids maintaining custom state machines, multiple Lambda functions, or bespoke routing logic. This reduces operational overhead while still supporting repeatable, observable execution.

Compared with the alternatives, option A introduces an agent plus API Gateway routing and multiple model choices, increasing configuration and runtime complexity. Option C requires hosting and scaling custom models on SageMaker AI, which adds significant operational burden and latency risk. Option D relies on multiple Lambda functions orchestrated by an agent, which adds more moving parts and increases cold-start and integration overhead. Option B most directly meets the requirements with the smallest operational footprint.

Option C is the correct solution because it uses Amazon Bedrock cross-Region inference profiles, which are explicitly designed to support regional data residency, private connectivity, and resilience with minimal operational overhead.

By using a Europe-scoped inference profile, the application ensures that all inference requests are routed only within European Regions where the FM is deployed, such as eu-central-1 and eu-west-3. This satisfies data residency requirements while still providing resilience and load distribution across Regions.

Configuring an Amazon Bedrock VPC endpoint ensures that all traffic remains on the AWS private network. No public endpoints are used, which aligns with the company’s private networking requirements.

Extending existing SCPs to allow inference profile usage ensures that employees can access the FM only in approved Regions, maintaining governance across the Control Tower environment.

Options A and B introduce unnecessary custom routing layers and EC2 management. Option D moves away from Amazon Bedrock entirely and increases operational complexity.

Therefore, Option C is the only solution that satisfies private access, regional confinement, governance controls, and low operational overhead.